I really enjoyed this conversation with Manolis. Here's the outline: 0:00 - Introduction 6:20 - Epigenome 10:28 - Evolution 15:26 - Neanderthals 27:15 - Origin of life on Earth 43:44 - Life is a fight against physics 49:56 - Life as a set of transformations 51:35 - Time scales 1:00:31 - Transformations of ideas in human civilization 1:05:19 - Life is more than a rat race 1:13:18 - Life sucks sometimes and that's okay 1:30:16 - Getting older 1:36:21 - The best of MIT 1:49:01 - Poem 1: The Snow 2:01:52 - Love 2:06:16 - Poem 2: The Tide Waters

Hi Lex, I'm a super big fan and ex-defunct-educator within a small community in Central Washington. I like to think I take every step with love as best as I can. I love your videos and was initially enamored by your love preeching and stayed because I believe in a diverse audience like you do. I was wondering if you've ever had a regular ex-math teacher /sub as a guest in your podcast? I think a ton of educators will be inspired by it! Hope this message finds you well! Thanks for what you do and have a great day! I can only think of Eddie Woo from Tedtalks.

Ooplljo

Observation if the energy that created all life is, then awareness creates an awakening within connects all life my DNA revealed information about me that goes back nine thousand years, ego kills, thank you Lex for your hard work and have a profitable day 💗💗💗experience the energy 💗💗

How can he say with such confidence say that Life start in the sea, he can't say that for fact, let's assume we did,we where the only thing that evolved from the sea, what about the theory that we've come from apes, more guess work ,he made a comment regarding Neanderthal and except for one finger bone, are you telling me that all that could be found is one finger bone??? Which until few years ago did not exist. I have also been cave diving and sound spiders with no eyes because there in the darkness all the time everything you find down has no eyes.

Feel free to have Manolis on the podcast AS MUCH AS YOU WANT !!

Please do Lex.

Same

I understand and agree with your sentiment.

@Tony Vega I'm sure Lex appreciates you giving him permission

@Tony Vega ll

I think these two conversations with Manolis are the best you’ve done. He is such a wonderful combination of great intellect, story-teller, teacher, gentle humanist and poet that I could listen to him for hours. Especially when he’s prompted by such a clever set of questions that you put to him. Thank you both so much for these two sessions. 👍💕

What of the big foot beings that live on Earth

Totally agree. Most brilliant person I may have ever heard.

You are so damn right! I find this conversation one of the most captivating I have ever listened to! Manolis is brilliant in every aspect !

Feeling exactly the same

probably my favorite two conversations so far! thank you both!!! :)

Lex: I'm Russian, I romanticize suffering Manolis: hold my beer

But we keep defying them

Manolis: I’m Greek, we gave the world logic and reason 🇬🇷

Hey man, just wanna say... I actually rate you over Joe Rogan big time. I like your way of interviewing, and your the only podcast I get super excited about listening to regardless of who is on, purely because you have a way of really letting your guests shine through, in a way that also makes you shine! So... keep up the great work, and keeping doing what you do.

Lex makes Joe look like a comedy thug….and don’t get me wrong I love Joe too!

@Eric Anderson I agree, these are two people who offer a different perspective and a both great in their field. Why is it people feel they have to have only one favourite then deem the rest as crap. Talk about ripping yourself off and insulting, not to mention small minded.

You don’t need to compare one over the other….. they are different people and there perspectives will touch different ppl differently.it’s all about perspective I don’t think one is better then the other, they both have unbelievably amazing interviews with all sorts of amazing people.

I don't even listen to rogan anymore. Unless he nabs someone really special.

Lex, I can respect that you want your craft and your manner of doing so to be accepted by the viewers but I wouldn't give 2 $hits about some random negative a$$holes comments. You do an awesome job at getting your guests to dig deep within themselves and share their feelings on an amazingly wide range of topics. Just keep being yourself. Your genuine curiosity is what makes your interviews such a captivating show to watch. I can honestly say that I've never seen an interview of yours that I didn't enjoy, even on subjects I'd never thought I'd have ANY interest in.

Yes another interview between my favorite robot and my favorite greek.

You haven’t met me...

lol

But who is which exactly lmao

Dude 😂

Hahahahaha

I am just amazed by the velocity at which Lex puts the podcast. And the best part is that there is no compromise on the quality of the content either. So much to learn from him !

Wow. The amount of doors that I didn't even know that I could walk through. Fantastic insight. I will listen to this again and again.

Yet again, Manolis just causally mentions so many jaw-dropping observations and facts, amazing!

Just as I start feeling like a huge dummy for not comprehending the conversation, Lex shuts his eyes and says "wait.." Then I feel better. 😃

You just made me laugh

Wow. The amount of doors that I didn't even know that I could walk through. Fantastic insight. I will listen to this again and again.

Probably the most fascinating interview that I've ever seen and heard in my life. Manolis is a treasure to us all. All these politicians and congressmen and supposedly community leaders who're incompetent and creating havoc in our lives, should spend 5 min with Manolis, shut up their mouths and listen to every word out of Manolis' mouth, say yes sir and try to implement it in our lives. Thank you Lex and Thank you Manolis for enriching my life today.

I agree 100% with your analysis of most politicians. I think politicians tend to attract narcissistic and opportunistic greed for power and money. I am so sad to see how there is so little gratitude for what is good.

Also listen to Joscha Bach and Lisa Feldman. Just as great, but of course no need to compare. All are amazing and make you go wow so many times during conversation.

To be honest, I'm not impressed by a scientist who postulates our ancestors committed the genocide of every other hominid on the planet on the basis of pure conjecture [21:32]. That's a very serious accusation to level against our ancestors and our race as a whole - a very serious thing to imply is simply 'in our makeup'. It's one thing to forward such a hypothesis if based on evidence but this is based on presumption, nothing more. No mass graves have been found, no war zones excavated, no slaughtered tribes. There are also a great deal of other factors that could lead to the disappearance of the other hominids. So, personally, I think Manolis should consider what advertising this unfounded hypothesis means to those hearing it who trust his word as truth due to his expertise - he does not make it clear that the actual facts of the matter are completely unknown and the extinction could equally be due to e.g. us carrying a fatal disease to isolated tribes with low immunity in parallel to the Spanish landing in S.America. I am not suggesting he should not state the hypothesis, just that he does it clumsily and appears unaware how very powerful and demoralising what he is stating is to young people etc. We have enough people walking around saying we're nothing but destructive, power mad parasites that deserve to go extinct without expert scientists dropping bombs like this without any evidence backing up those statements.

Manolis needs to have his own podcast or must appear here every month.

That's the law from now on

Once he starts talking about the meaningful of life it's very inspiring, then depressing, then even more depressing, and finally resolves to inspiring. Very honest, candid, and meaningful. Interesting to think about it.

Lex, you’re a beast. You know it’s ok to take a couple days off just to relax and have fun. But i do appreciate the veracity and speed at which your podcasts keep coming out!

kyle roan The Dr. knows!

Manolis, massive fan - please start writing a book for the masses. You are so good at explaining, humanity will miss out on your truly amazing enthusiasm and knowledge.

At 1:04:26 Lex whispering in awe "so brilliant" is everything. So glad to see Manolis back in this podcast. One of the few humans who can talk of Alexander the Great and ribosomes in the same convo. Gotta love him

Amazing. One of my life-changing moments was seeing children in Iraq. In the worst possible situation of war. They played soccer with rolled up shirts with bare feet, hungry, thirsty, hot. They laughed, they played.

@Juan Cantú war sounds fun

@Amanda Jean kinda a shame most of us never see that hope. There's alot to be said for the old ways...good and bad. At least humans were people then. Oh well. If we lose enough, and suffer enough, they'll bring the old ways back.

@Juan Cantú I was building walls in Baghdad most of the time and delivering supplies. Most of that time was witnessing suffering, but it was a beautiful gift and life lesson to catch glimpses of hope for humanity.

Wow.

I was a medic for an army combat support hospital in Baghdad and in Mosul, Iraq, and I only got to see their physical suffering and death. I haven’t felt positive about having experienced what I did in Iraq until just now reading your comment.

I adore this guy, Manolis Kellis, I wish we had more people like him on Earth!

Me too!

Incredible. Most informative podcast I’ve ever listened to!

Manolis Kellis is a national treasure.

man you could have this guy on like 5 times a year and everyone would approve

Manolis must have the best understanding of who we are that i have ever heard what a amazing human

Lex- thank you man. This is one of the most moving conversations about life I have ever seen. Manolis is amazing. Grateful for your show and this episode in particular.

amazing conversation such a privilege to be able to listen and watch this for free. Thank you lex you have become my new favorite podcaster. You have such amazing guests and the questions you ask are so perfect, things you would never hear from these people through any other medium really. Thank you 🙏

Lex, He is one of my favorite guests you interview. Hopefully another one with him again soon!

This podcast is amazing. Guests like Manolis and Joscha have truly impacted my outlook on life. Thanks for this I'm glad I still have another episode with him to watch after this :)

I think you should make a regular podcast with Manolis every other month. Absolute geniuses!

"Life does not start after the next milestone" - Manolis Kellis

Love this guy, the prayer he gave in the first podcast that he said he does with his children was so simple and beautiful. I feel lucky to be the same species as this guy.

I've been a student of biology for most of my life until my fascination with systems (and a paycheck) brought my path to software instead, and I gotta say, this video has some of the biggest mind-blowers I've experienced since first reading Dawkins during my school years. The world needs more Manolis, and thank you Lex for sharing him with us!

This is a mine of gold. I feel blessed Alex, you made me love science more than I had never believed in God. One of the best interviews I’ve seen in my life

Been very addicted to your chats, Lex. I really appreciate them! The two with Manolis have been particularly interesting.

This conversation blows me away. I'm gonna have to listen to it a couple more times to internalize what is being said. Lex has a knack for asking amazing questions and getting amazing answers.

This episode was recommended to me by YT the day I turned 42. 😂 one of your best Lex. This guy is brilliant!

Our favorite guest! Thank you Lex

I don't think I could ever listen to enough from this guest, he just blows my mind on so many levels! Thank you Lex for having the greatest podcast there is!! ♡

Great job Lex! One of my favorite podcasts so far. "If you know who you are, what other people think about you, only teaches you about them" really stuck with me.

One of the best interviews...thank you!

Easily one of my favorite podcast episodes!! I hope you keep bringing him along! And if you happen to read this Lex, you are doing amazing, keep striving to do what you want to do, and don’t listen to the haters now that you have FU money! Oh and get off the comments.

Dear Lex Thank you so much for your great podcat and I love Manolis, he is very intelligent and explains everything with passion that creates passion in the audience for science :) thank you guys for existing!

i dream of encountering in my life teachers like Manolis and schoolmates like Lex. and i'm 53.

A brilliant man and a mind-blowing interview Lex. I'm still laughing at how blown away you got while trying to keep it together and Manolis snapping you back to reality.

Lex, what an amazing job you do with the questions you ask! I especially love the romantic and philosophical ones. I’m a new listener to your podcast and it’s brought great joy in a time of relative personal despair. Thanks again!

@6ixpool Just did! It was excellent! Thanks for the recommendation! :)

This podcast is fantastic. Try listening to his 1st interview with mannolis which to me was 10x more mind-blowing!

Lex, as a student in my mid 20’s, you’re an inspiration!

This episode is masterful. The discussion gained superfluidity levels, beautifully converging on origins of life, evolution, civilization, arts, and emotions. Many thanks to Lex and Manolis for sharing this wonderful experience with all of us.

Perhaps my favourite podcast of your entire list. Excellent questions, and even better answers. Manolis is an expect that actually understands how to communicate his ideas subject to a high degree for people outside of biology. Perfect blend of philosophy and biology. Thank you for this gift of an episode Lex

"even if my monotone.. robotic voice sometimes sounds otherwise" 😂 that made my day. You're awesome man! I love the self call out. Honesty level: over 9000!

I loved loved loved the last podcast you did with Manolis, thanks so much for continuing the conversation

Just listened to first 15 minutes and my mind is repeating just one word: Beautiful.... Just beautiful..... Thanks for your efforts Lex- this is meditation- pondering over big unbounded questions... Just beautiful!

Lex: "Using the internet without express vpn is like going to the bathroom and not closing the door" Me listening in the bathroom with an open door: How did he know 😱

When friends complain about Google spying I always tell them I don't care if they know how long I was in the bathroom or what I read or listened to. ;-)

Too funny. Im reading this in the bathroom..yes with an open door

You don't have VPN. That's how 😂

Fantastic conversation! Thank you Lex. Indeed, we need reminders to embrace suffering in our jurney.

So happy I was introduced to.this dude. What a great selection of guests!

These are the podcasts that I am eternally grateful for. My perspective is widened, my mind is blown. Thank you for having the kind of conversations you have with such great guests, Lex Fridman.

My oh my! I literally laughed and cried whilst listening to this podcast. People in the subway car looked at me like I must have gone mad. Manolis is such an inspiration! One of best of Lex' podcast to date to be sure. Very much look forward to the next two Manolis appearances.

I find Manolis Kellis as one of my elusive heroes. Please have him on again :) he's great.

gosh what an absolute GEM Manolis is. Thank you for 3 mind blowing interviews with him and more please.

2 awesome people having a great talk. I love podcasts, I've listened to a lot of them, and this one is in my top list!

You are just a humble, lovable light. You are clearly on a journey and its nice to see someone without his cup full. We need more perspectives like yours in this increasingly partisan and dark time. Thank you Lex!

I love that magic spoon sponsored Lex Fridman AND Tim Dillon, literally legendary.

Hey your podcast is amazing. I love it. Obviously don’t always understand as I’m not as intelligent as you or your guests but incredibly interesting.

He's the best guy ever on podcast.truly fascinating experience to watch this

This is now my favorite podcast lex. Such interesting guests all the time.

Lex you and Manolis are awesome, i love how he can break down so much human accumulation and poetically tie is to our modern dilemmas, braco guys thank you!

Dear Lex, this has been one of my favorite podcast so far! And would like to share it with family and friends, unfortunately most of them only speak spanish. Some subtitles would be awesome!! Thanks and keep up with the great work!

The Lex Fridman podcast has become one of the most important pieces of content in my life. Thank you, Lex as well as all of your brilliant and wonderful guests.

Lex please make him a regular guest. Talk about a brilliant mind who just happens to not have his own podcast who more people need to hear from on a regular basis! I loved every minute of it. Please keep up the good work!

This is the type of podcast that changes lives.

This is such a beautiful podcast. Thank you both!

One of my all time favorite videos on YouTube right now. Seriously phenomenal conversation. Bravo gentleman.

great podcast, i'm going to watch his symposium next

It's so enjoyable to listen to these conversations with Manolis. I hope he comes onto the podcast more. He's brilliant, and has a beautiful understanding, perspective, approach to life and the world.

"Again, being greek" Great self awareness there Manolis. Stereotypes exist for a reason, and this is always a fun one.

Loved this talk, thank you so much Lex!! : )

Such a aweome guy. Makes everything so relatable.

Yes, he looks and sound as a very interesting fellow!

*an

I really enjoy your show, Lex. It's been a wonderful new find this year. Thank you. Merry Christmas.

This is the first time in my (long) life that I didn't switch off at some point when a podcast drifted from hard core science content into the murky waters of meaning of life and such. To the contrary here. This guy is sensational! Thank you, Lex!

Could listen to this guy all day! Easy on the eyes, smooth voice and extremely intelligent. Great podcast / video!

Thanks to both of you for this amazing interview.

I’m a new fan of your podcast (Thank you, Joe Rogan) and am fascinated with the content in the conversations you have with these brilliant guests. I’m almost embarrassed to admit that I stayed up until 5am this morning to finish this one. Truly eye opening and I wish I had found you sooner but thankful to have made this discovery and look forward to observing and contemplating more of your discussions.

Watched both of these twice. He's an interesting fellow. He is soft in voice, but, as if trying to enable you to find your own answers. Beautiful.

What an amazing interview Thank you guys for the conversations.

Truly this is one of my favorite podcasts I've ever seen. And if it were not for lex I would have never discovered this man or his insights and perspectives. Lex thank you very much. You inspire many many people.

Hear hear!

Congrats on another great upload, your journey has been inspiring me.

This is one of the best conversations I have ever listen to! Manolis is brilliant in every aspect ! His knowledge, passion and personality, blend into the most captivating dialogue about life and humanity!

Very satisfying discussions, so full of deep ideas!

We asked for it, Lex and Manolis delivered it. Thank you both 😊

Wow this guy is great at giving an intuition on these complex topics

Thank you Lex! Waiting for this! Can't get enough of listening to this guy.

This is profound and incredibly useful. I especially liked his advice on the meaning life. Accepting suffering and flaws as part of the struggle that gives life meaning. The journey is what matters and through struggle we can live a great life. Excellent advice especially in these times of instant gratification and entitlement.

This interview felt like listening at two adults discussing, when you were a little kid.

This is a mindblowing podcast Lex! Thank you so much for sharing with us the force of your friendship with this extraordinary and sweet person..! This is humanity at its best!! Learn so much, open new doors to look into... really, mindblowing! Thanks, thanks, thanks!!!

Can't get enough of this channel. This guys an unbelievable genius ! Love it...

Amazing Lex. What an enlightening talk!. Makes my day. Thank You.

Best Saturday afternoon I've spent in a long while. Thanks to both of you.

You are hilarious Lex. I really enjoy your monotone voice podcasts. It puts me in a calm state. I'm a new fan :)

I love how you guys started it off the same way as last time. 😂

Maravilloso e inspirador!! Felicidades por esta entrevista!! 🤗😁

As a fellow compatriot (Greek) Mr. Manolis Kellis (Kamvisellis) is such an inspiration...! Thank for bringing him to your podcast Lex such a joyful listening experience! 😊👌

Lex - this was a fantastic podcast. I really enjoyed the guest and the topics discussed. it really helped me to hear this insight about life, evolutionary and existentially. You're doing great my man.

This podcast is so good. Lex is a fantastic listener, and lets the guest completely flesh out the concept.