Manchester United goalkeeper David de Gea has a groin problem and is not expected to play, while midfielder Paul Pogba is out with an ankle injury.
Aaron Wan-Bissaka, Anthony Martial and Luke Shaw face fitness tests, with Jesse Lingard, Phil Jones, Diogo Dalot and Mason Greenwood also doubts.
Liverpool will monitor goalkeeper Alisson, who could return after two months out with a calf problem.
Centre-back Joel Matip has missed the last two games but may be fit to play.
The Reds are also hopeful Mohamed Salah will feature despite the ankle injury he suffered against Leicester.
Manchester United manager Ole Gunnar Solskjaer: "I've never felt it [the United job] is too big for me. I'm confident in what we're trying to do and I'm confident in my staff.
"We do have a plan and we know that we've made some decisions that maybe in the short-term would harm us, but we know in the long-term will benefit us.
"But results are always the main thing and we can move forward quicker if we get results and performances."
Liverpool manager Jurgen Klopp: "How much do I enjoy these type of occasions? A lot! It's the salt in the soup!
"They [Manchester United] said it - we are the perfect opponent. I don't think there are too many teams who want to play against us at the moment - it looks like Man United are the only one!"
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