Once again, science has cured every illness known to mice!

Exactly

That makes me sad

Pun Mun that makes me happy

For once, we turned something we hate to something that can help us live longer, better Edit: forget everything you just read mice are cool, just not the ones shitting on my grandma’s pots before she makes dinner

This message approved by the Mice Longevity Program Initiative.

12:21 (For a mouse) Reduce amino acid intake Intermittent fasting Stay slightly cool 14:18 (For a person) Avoid DNA damage Eat less Eat less protein High intensity interval training Be cold Be hot So protect yourself from ultraviolet radiation in sunlight, and engage the survival instinct by being hungry sometimes, running yourself almost ragged, and/or cooling/heating your body too much

This is basically how soldiers live or how most people live in Third world countries. Also if that was the case then why do the Kings and Queens of England live so long, they definitely dont starve themselves

This sounds like the life of every poor person. Why don't they live forever?

@Andrew L bruh that's a gross oversimplification

So if we assume all these things actually work (and we should not just assume this), then the next question should be which ones work to what extent? The wealthy appear to age less than the dirt poor in wealthy nations. So what is the common thread? Less UV, would appear to be significant. Add to that the fact that those who sunbathe a lot when young tend to look much older as they age and this one does appear to hold up. This may, in fact, be the most significant factor, at least to the exterior. Let's look at diet. When we look at "rich people food" one common observation is that potions tend to actually be smaller than the common person would like. Surely, the rich can eat whenever they want. Why are "rich" meals so small? Now it may be that they eat smaller portions more frequently. This may hold up as the less frequently you eat, the more your body tries to store fat. So the answer may be to eat smaller portions over three meals and two "snacks" per day (five meals rather than three if you will). But we also see the longest lived populations in small pockets of the world tend to eat things like sweet potato (which has protein). So what is the solution? Who do you believe? This one either does not hold up or requires further study. It may be that certain types of protein are more harmful than others and anthropology may hold some clues. If we look at religion, many religions have dietary restrictions. Pork is a common one. Some should observe how those who follow these beliefs age and it does appear to hold some water as studies show that many religious people age slower. But wait. Many of these same groups fast at times. So now we cannot be entirely sure which factor we are measuring. And to further complicate things, the religious communities also seem to deal with stress better and is that because they believe in something greater than themselves or are the practices in the video the reason? Is it a combination? Do you handle stress better when you limit diet voluntarily and fast on occasion? Again, we see we need further study. Finally, we get to exercise. This one is not really disputed. We know that vigorous exercise opens up the circulation and flow of oxygen and other things in the body and that it improves general health. So in summary, it would appear that avoiding sun and vigorous exercise are key. There are hints that dietary restriction is helpful but to what extent and by how much, we are not sure. There are also indications that other factors may account for a portion of the effects such as metal health and belief and/or overall stress. But don't take my word for it either. Look into it yourself.

I am so impressed with the science discoveries humans have made. Every time I watch a video like this, I realize not only that I don't know anything, but also how close we are to inventing something I thought was impossible.

We have countless diseases that we don't even know what causes them, let alone be able to cure them. There is the false sense that medicine is truly advanced, but if you look closely, you will realise how we don't really know anything yet. Cancer, All auto-immune diseases, genetic diseases, and countless others. Hell, we didn't even cure hair-loss yet.

@Avgoustinos P if we all go bald young then we never have to deal with hair loss!

Like zombies

@PeanutHead yeah I'll pass on that, thank you xD

@Avgoustinos P mate medicine is advanced , there are barely any diseases whose cause we do not know , cancer ? we know the cause , genetic diseases ? we know the cause ...... moreover cancer can be cured in 50% of the cases , the remaining 50% fail as the cancer has already reached 3rd or 4th stage , and this too is most of the times caused because of the lack of regular check ups and cancer tests , meaning that its the fault of the victim himself .

Super interesting topic. This was actually part of my Master Driploma in immunology. One important reason for aging you did not mention at 4.30 min, are the effects of infections in driving ageing forward. My research showed that viral and bacterial infection are also responsible for ageing and the development of autoimmune diseases in old individuals. Less sick=lesser ageing process

I have a good immune system. I rarely get sick. I'm 40. I look 23.

My mom rarely got sick, she is the fittest individual I know. But some years ago she got diagnosed with Autoimmune diseases (MCTD & more ) and is struggling a lot. So it perplexes me what caused it.

@James Watson Atheist Gamer hey what is your diet?

@James Watson Atheist Gamer and how careful are you with hygiene?

@Ariana Askari Fruit. Veg, a bit of protein. Vitamins/minerals. Fruit juice/water. Bcaa's. L-glutamine/creatine. Fibre. Nuts. Rice. Pasta

Hi Derek, you were my physics tutor at Matrix like 16 years ago and I just found out that you run Veratisium. Haha that's insane. Congrats on the success 🙌

Crazy

Hell of a coincidence. And he's very successful also.

Hey do you remember me

@Michael von Reich yup

Sinclair takes alot of criticism from the scientific community because he is clearly on to valid theories , literally he is breaking boundaries and showing us that living longer is totally achievable with our current state of tech

@Sweet bromine It's not that people aren't just enrolling, it's that they can't. Education in the US is a business and the financial level of entry is prohibitive relative to even just 25 years ago. I agree, that is a travesty!

I think Professor Sinclair will be a key figure in aging research for at least the next 300 years or so.

well done. well done. ;)

He does look like he Benjamin Button'd parts of his body and face.

@Richard Smith he looks his age. Even he can't stop his own aging. But I hope he finds a way.

@Emma Phi He said he changed his biological age from 60 to 31

@BlueSea Correct, and he gauges this using a method established in recent decades for determining the amount of erroneously accumulated molecular methyl groups in our cells' DNA bundles, called the "Horvath Clock" The reason this is significant is that DNA methylation has one the most consistent links between overall biological damage an organism has accumulated over its life, and Based on statistical data, When an organism is most likely to experience "biological mortality" (most people refer to this as dyeing from old age)

You can tell he really likes his work with how excited he gets by it. This is a really interesting topic honestly would be nice if it ever got to this point of reversing aging.

The get your hopes up, the rich will hog everything

I hope I'm still alive to see it! :D

@On Flight so what if they hog everything. the more they buy it, the more they fund the technology, allowing for easier access to the public. Just because you earn less than someone else DOES NOT mean you are morally superior.

@Soumil Yarlagadda wtf? You won't get it anytime soon, and who's to say my FAMILIES won't be rich in 2023 seriously? Can't even begin to tell 2023 or 2024 will be the hallmark of my life

To anyone watching this video, I HIGHLY recommend reading Professor Sinclairs book, or downloading the self-narrated audio book. He goes into a lot more detail explaining how these cellular functions work. Greate work summarising this Derek!

He also has a podcast in his Channel that contains new information

I'm glad you mentioned the self-narrated audio book version... still not going to listen to it though

Six things to do 0) 14:23 Avoid DNA damage 1) 14:29 Eat less 2) 14:33 Eat less protein 3) 14:39 Do HIITs 4) 14:48 Be cold 5) 14:51 Be hot

I wish i was the 5th one

Only I have a problem with is "Eat less protein", I love chicken & shrimp

The fact that your list starts at 0 makes me think you're a programmer

Fasting looks like it’s good for allowing the body to heal itself.

@Mr. Gabila Body builders are not gonna like that lol they would be thinking "Do I want to stay young or do I want to get buff?"

Derek seems so productive. Consistently making consistent quality videos without a dip. He should perhaps also make productivity vdo too, giving advice (that works) to make the most out of the time we already have.

Adderrall

Epigenetics is not just do to breaks in the DNA, there are proteins that actively methylate or acetylate to turn genes on and off. The epigenetics have a part to play with aging but our body is also responcible for these changes. Also Dolly the sheep that was cloned also aged more aggressively and had signs of being super old. I know in the lab we have cloned mice and not seen the same results. Additionally, if you take the DNA out of a fertilized egg (not mitochondrial DNA but nuclear), you can put any DNA in there and the cell will divide into many cells with the same function as the DNA put in. I think this is viable research but permanent cells like the retina that has no stem cells (very few stem cells) and is stuck in G0 are very special compared to most of the cells in the human body. Also there are cells that are immunopriveledged, would those work similar to the retina which has the protection of the blood brain barrier except for maybe the optic disc? Also with aging major changes happen throughout the body. Would I be able to grow again? Would I lose the ability to do automatic cerebeller tasks like walking or playing the drums? Would my brain reset the synapses to when I was young? Additionally, we have all kinds of micro organisms that live in us, eukaryotic and prokaryotic like bacteria, fungi and maybe even some parasites and protazoa. Moreover, there are viruses literally everywhere and with the pathogenic retroviruses and even RNA viruses which replicate in the nucleus, there seem to be a lot of things that must be explored before this is clinically relevant. I wonder if this could cause autoimmunity or help with autoimmunity. How would this stimulation affect the stem cells in the blood or during pregnancy or the immune system. Imagine something like Tregs proliferating or a cancer cell that should have been killed by the immune system turning into an earlier stage and dividing? Could this help with cancer? Also if a person cannot see I think by 2 years old then the pathway is lost, so is the developmental visual pathway the same as with mice? I love this research and hope it comes to past and helps all of us live more fruitful lives. Okay one more thing before I'm done (sorry), what about the haploid cells in the body and the permanent stem cells like RBC, platelets, lymphocytes and all the leukocytes? There are just so many things to consider, it's overwhelming but I really hope this works.

I wouldn't underestimate science and technology.

It's all fun and games until you find out that David Sinclair's real age is 150 years.

correction: 1500 years

Cool Air by H.P. Lovecraft

@Kasqtie He is the one who built the Pyramids.

@Kasqtie Correction: *_1,500,000 years_*

Franz Xaver Fuchsberger the queen is his daughter

What I love about your video is that it is not too short nor too long yet compact with information! Keep it up! Thumbs up!

I think the big question with the jellyfish premise is - how many various cell types does a jellyfish have vs a human body? I think this in itself will leave the human body with an inability to do such

The jellyfish is still relevant due to a key feature mentioned in the introduction: that this jellyfish has no senescent cells. The reasons for this are genetic and molecular in nature which is common among all life. Part of Dr Sinclair’s work is finding ways to reset the methylation and restore the epigenome, basically to undo senescence and restore correct healthy cellular function.

@Haitchpeasauce explain as if I'm 5yr old....

@kitchen King all cells contain the same genetic code, but the packaging of those genes affects how the cell behaves; what proteins the cell makes. Over time this packaging becomes corrupted, this is part of the aging process. If a jellyfish can consistently reset its cells to the youthful state, then we have something to learn from them in figuring out how to reverse aging.

@Haitchpeasauce wow.....but why does this packaging becomes corrupted over the years???!!

@kitchen King I recommend listening to David Sinclair's podcast "Lifespan" which goes into detail about this. It's to do with how cells repair broken DNA by unpacking and then repacking the DNA after fixing the break, and in doing so the epigenetic markers sometimes do not return to the correct place, causing misreads of the genes. I won't describe further because it's best to hear this from Dr Sinclair.

Thank you so much for this video Derek & David! After listening about genes in this video, I'd love a video around the dec2 gene.. or even about why we require sleep exactly in general.. 👌😅

I also agree with some of the comments here that a revisit to this subject would be amazing, not that this video isn’t in depth enough, it is a bank of fascinating knowledge, the topic is just so appealing that we would love to have more. 😂

I love how failure in applying epigenomic therapy is just "become a tumor". That's the spectrum of possibilities for anti-aging therapy in tissue: grow older, stay the same, grow younger, or become a tumor. I imagine becoming a tumor as something like Star Trek the motion picture where the transporter failed and "what we got back didn't live long"...

These YouTube tutorials are getting more and more advanced

GAHAHAHAHA

I have to note here he never said 'caloric restriction' yet Derek took it that way, the doctor said Fasting, eating less. Restricting calories can be hazardous as proven in the Minnesota Starvation experiment. There's a huge difference there and one leads to the benefits of anti aging while the other does not.

It actually can summary to don't live too comfort. That all. Always wonder why most of the soldier live longer than normal men ? Now I don't understand why.

I laughed hard at this

@kyle fer Can you explain the difference. I don't understand the difference and am confused. I'll also try to search Google.

This is amazing stuff. I'm fully convinced this will happen in the next 10 years. Technology is advancing so quickly.

Oh interesting! A lot of these points are mentioned in a book called "The Forever Dog" that explores how we can make dogs live longer, and how it reflects the aging of humans since there are so many overlapping environmental factors.

Thanks for sharing! I will check it out.

Good to know that me forgetting to eat and not eating much meat might help me live longer 😂 Though I have to say, that for me after not eating properly for 2 year made me much weaker, and when checked my vitamin levels, I had lots of deficiencies including protein. It's probably partially related to me passing to the second half of 20s, and staring to really see effects of aging, but I also think office life coupled with poor diet/skipped meals played a big part too. Perhaps while fasting and limiting protein intake, a person should have an active lifestyle, otherwise the body doesn't turn on longevity genes 🤔 How do I keep my vitamin deficiencies at bay, but also trigger longevity genes?

Meat doesnt show any issues if you have a high plant intake. Also muscle loss and weighing very little gives major issues wwhen you get old and affects your longevity. Its better to be slightly obese than really skinny( low fat and low muscle mass) Fasting show no to little benefits over regular dieting, in terms of health markers, when caloric intake is equated. Dairy products and eggs are a great way to ensure you get enough nutrients. its what i did when i didnt eat meat. and i never got any deficiencies, except vitamin D. Ill provide the research papers if you want the evidence

Dr Sinclair was famous within the biomedical community as far back as 12 years ago for ingesting Sirtuin (a molecule that he was researching on) despite lack of clinical studies . Professors at my university used to tell the class how reckless his action was, but fast forward 12 years it looks like his self-medication is working. (Source - a biomedical science student at Monash University at 2010)

We'll find out in 50 or so years if it's working or not. Either he surpasses 100 or not. A mouse would take even less time.

He seems to be extremely confident in his research. All the power to him, I hope the self-medication doesn't turn out to be a huge mistake.

Imagine how much someone could help if they had a longer life.This sounds amazing.

Most people do nothing to help , one video of a public attack where everyone just stands around recording on their phone.

It is physically impossible to say "mitochondria" without adding an explanation that its a "powerhouse of a cell".

Mitochondria

It's a powerhouse of a cell

Damnit, I was close

@Jean-Baptiste I see what you did there

Mitochondria

In the trilogy, Arc of a Scythe, by Neil Shusterman, humanity had conquered death and aging. I don’t know what his inspirations were but the way the professor described reversing the age of the eyes of the mice reminded me of the book series.

This actually helped to explain why I look so young compared to others I’ve have had a eating disorder about as early as I can remember which has severely reduced my caloric intake for years weighing at a maximum of 125 while being 6’2 (still working on it), I’m 20 now and I still get mistaken for a high schooler which is always funny as hell to me

Lol, there are high schoolers that are 18 years old, you get mistaken for a high schooler because you're still basically that age.

@ThunderCats I mean like sophmores/freshmen my guy

There could definitely be a correlation

honestly this is not a good enough example. I used to be told I looked like a teenager till basically 26, and i didn't have a super healthy lifestyle. the effects of aging actually start looking up in 30s and 40s. Also, a lot depends on your natural body and face type, i.e., people with slimmer body and slim face will def look younger than their age compared to someone stockier or broad faced.

I don't think you needed to clarify the mitochondria's function. Every baby comes out of the womb with the ancestral knowledge that " The mitochondria is the powerhouse of the cell". Great video! I was very excited to see Sinclair contribute, he's one of my biggest role models.

Thank you! And you made me finally understand (and so simply!) how epigenetics actually works :) cheers!

I wonder if the cells could be reset by the factors and changed while the system was off, like a way to influence phenotypes at the same time as the age reversal in organisms that already exist.

Try to guess how old Prof. Sinclair is before he tells you...

42? I did this before I saw him too.

57

29

How can we do the tests to figure out how old are we biologically - and how to make life changes to make ourselves biologically younger like the Prof did?

48

This stuff is so amazing and we need so much more. Much much more.

1. Reduce sugar intake 2. Reduce protein intake 3. Intermittent fasting 4. Exercise 5. Train body to bear Uncomfortable temperatures 6. Avoid chromosome damage (excessive smoke,drink,sun) 7. Eat veggies, fruits & nuts 8. Reduce stress, meditate 9. Take Vitamin supplements if diet not varied 10. Take NMN supplements Pray (that no bad luck befalls) And enjoy your 150th!

George Burns: Hold by brandy and my cigar.

Reducing stress on genes according to the video would shorten life but that doesn't make sense to me...so I think certain stresses are good while others, say relationship stresses, are bad.

At that point, I'd rather just live a comfortable normal life span and age normally.

@Justin Joy Well, if you followed the rules for a couple of months, you would start enjoying it. It really works like this.

@david d Not necessarily, too much stress can be detrimental but not enough stress has negative effects as well. Like most things in like, it's all about balance.

Go professor! I wish I could keep my parents forever.

This video is very nice! I like this topic and the way it has been described. Good Job Derek!

When they were discussing the shape of the different proteins makes me think about the recent breakthrough where AI was able to model all the shapes of known proteins. This breakthrough is going to be incredibly helpful for this live increasing research. 👍

Professor Sinclair looks like he’s been the subject of his own research.

You look like amado from boruto

@Obb Bob Haha wow you're right

Well, he originally appeared as 60 to his tests, and now appears to be in his thirties to the tests.

@Tristan Mitchell yes but his eyes are 15

He is. He's publicly said that he skips breakfast (intermittent fasting), eats basically no sugar, and takes NMN (one of the chemicals that was injected into the mice) daily, along with a few other supplements.

It would be huge if we could extend our "twenties" and "thirties" twice as much, adding 20 more years. I think that would give people more time to figure themselves out and accumulate enough money to live out their dreams while they are young.

I love the fact that most of these things were always seen as healthy, like to fast, or to take cold showers, but also to wear sunscreen, and do tough exercises and now they seem to let you age slower...

I would love to see the resulting effect of cortisol from putting your body in stress/protect mode. It seems almost counterintuitive to put your body in stress mode which resides your cortisol that in turn results in negative effects

After all the research I did into intermittent fasting, I just knew the topic would come up here. In short, it makes your cells more efficient. The process of autophagy will make your good cells, eat the bad ones (so to speak). Like the senescent cells mentioned around here 3:57 Do not underestimate the benefits of what a regular fasting regimen can do for your body. Remember, as a species, we did not evolve to gorge ourselves on 3 meals per day.

Thanks! Makes sense. The conditions that caused humans to intermittently fast were around for our entire evolution, minus a little peep at the end where our population exploded after the industrial revolution and food security improved significantly for most of these people. It makes complete sense that some of the mechanisms that keep us in top shape would've happened to evolve to be triggered by one of these conditions that was historically present.

I am a type 1 diabetic.. id love to see what my actual age is. My A1C's are usually pretty good but there has been a year or 2 where I ran higher then normal.. it would be amazing to see

Sugared hemoglobin unfortunately is an average, there still are higher levels of glucose, maybe you can get a pump not only for insulin when high glucose but also what you need when low. Such a modern pump does it also when you sleep.

Sometime in the possible near future: “Doc, I’m feeling a little too old, what can you do for me?” “Have you tried turning your epigenenome off and on again?”

it just works

This is a very good joke

Literally died reading this so gonna need to restart the genome

hold on... ok... now I'm a giant tumor. Wait... I think i did it wrong.

I’m playing Skyrim while reading this comment

Wow I loved this video, easy to digest and understand through the complexity of the information. But I had a question…. If part of reducing the speed of aging is being really hot or cold is there a optimum amount of time one she be exposed to either condition? Do really cold or hot showers help with this process?

This video immediately reminded me of the question "if you were offered immortality, would you take it" And i have learned it always depended on if it was just you, or if your friends would be too

You can always make new friends,and many people live happ without a biological family

@g s If I was as healthy as in 20 years old, sure I would live a really really long live, but if I was old, nah

This study and knowledge is priceless man. I am thrilled after knowing the process of aging. And I don't why but I recalled the memory of Avatar movie for some reason.

My DNA had a mutation and it gave me a tumour called epithelioid hemangioma it’s a rare condition I think it would be a good video to spread awareness of a rare cancer that can go unnoticed for years

We need to bring back the age of science where we would find something like this and test trial and error on ourselves. I know if I found that, putting it into myself in stages would be the absolute first thing I would do after publishing the data.

“I was biologically sixty and than I changed my life and become 31” that seems like something an evil scientist would say

Alchemical Reviews 75 actually

I want to know his diet and daily routine!

Cringe

@walperstyle 1,000mg β-Nicotinamide Mononucleotide 500 - 1,000mg Resveratrol 1,000mg Metformin Good luck getting the Metformin (it's prescription only), but that's what the Resveratrol is for. NMN = Sirtuin pathway Resveratrol = AMPk pathway Eat less red meat = mTOR pathway Of course plenty of water & physical activity cannot be substituted, but you asked his daily routine. And yes I've been doing all three for a little while now. 😉 Tips: Resveratrol is cheap and plentiful. Get some. NMN is ... sometimes pricey. My advice is to source it well. It's a special form of Vitamin B3 found in things like cabbage, avocado, broccoli. Of course you can't eat 1,000 avocados in a day, so you buy the NMN. Physically it is a white crystalline powder with a slightly bitter taste and very soluble in water. Also eating less red meat is free and might even save you money. I recommend upping your plant protein instead (peanut butter, cashew butter, sunflower butter, almond butter, things like avocado, hummus etc....) Pretty sure the good doctor also likes his fish & chicken. He doesn't abstain from meat entirely. Just make a burger, steak or ground chuck an occasion thing, rather than a daily or weekly thing.

"I turned my 96 year old body into a mostly 28 y/o and no one knew until a Tinder date went down on me & tasted the one thing you can't reverse."

Everything is impossible until someone does that. I just wish that I could be part of the people that can just slow aging meaningfully or even reverse it.

But you can, just do the 4 things or whatever that V recommends and it'll slow aging down

El problema esque cronológicamente no podemos

I'm glad the world is slowly learning more about epigenetics. Fun fact: Not just DNA is transferred to children, but a wide array of germs which determine how the brain ends up functioning. If you're a stressful or addiction-inclined person, your children are more likely to become stressed or addicted, and so on. The ethical implications are tremendous, though sadly we're still at the stage of trying to convince common people to think about whether or not they should become parents for extremely obvious reasons (finances, severe genetic deficits etc).

@Dave z Commonality refers to commonality. The fact that I'd never breed, and never have, is hard evidence that I'm not in the majority group. The same goes for thinking about epigenetics, genetics or the philosophy underlying procreation: These aren't normal, and I'm hoping they'll become more normal in the future. That being said, it's damn important that I don't pass on my shitty genes and germline (there's a giant list of deficits), which is why my physical brother's procreation is a severe problem, one that is firmly rooted in physical fact. CPS would agree as they've had to endure countless threats on their lives, as I have. So yes, if you believe procreation can't have extremely negative outcomes, if you believe all humans are equal and per extension biological information is meaningless, if you believe the suffering of children shouldn't be prevented or if you believe that there is no such thing as problematic biological information, that means we have a problem. Then again, that goes without saying as you've already implied it.

Altered Carbon is a novel (has a pretty good netflix adaptation as well) which tackles classism born from immortality. pretty good work

Muito bom.

You can tweak the DNA and use the immune system to clear wrinkles, Scars, Moles, Even palm lines. I know because that's happening to me at 48 so it's possible. 😁

I 🥶HAVE🥶 LUNG 🥶CANCER🥶 TAKING 🥶KEYTRUDA 🥶… is that what you were taking it will it make you look younger😂

Sinclair looks suspiciously young for his age, him being a 50 year old professor that studies anti-aging. Maybe he’ll one day turn into a super villain called something like “Professor Baby” or “Doctor Embryo”

professor immortal sound more badass.

@jc denton nah, its too badass...

The Timeless Toddler

Doctor Fetus in real life

I like how you picked most horrible names possible

You forgot #6…take an NMN supplement that also contains a strong antioxidant like resveratrol, and make sure the dosage is high. Also, there’s a company called Photozyme MD (for your skin) that has 3 different enzymes that heal DNA damage. That might be another good tip.

It's interesting because not all physiological processes are reversed just by restoring cellular function. For example, osseous disease such as osteoarthritis and degenerative disc disease are unlikely to heal and may even worsen if you were to deliver OSK to the entire body.

This is quality content 👍

I feel like after listening to this explanation i would say that reversing age isn’t exactly true but personally restoring age is more accurate

I really want an update on this video as this is 2,5 years old already which isn't that much in general but in the field of scientific biological advancements it is a lot.

Love it when people like this have the ability to break down complex biological and scientific information into sentences, illustrations and examples which people like me can totally understand. I was never a great student growing up, especially with this stuff, but now have a genuine interest and appreciate it way more as I approach my mid 40's. Granted, I'd rewind a few times, but I was also sincerely interested and it felt really good to actually grasp everything. Thank you, gentlemen!!🙏🏽

"if you can't explain it simply, you don't understand it well enough" -someone, idk, the internet can't seem to agree on one

@Sage Crockett "Poisonous injections"? "Did not exist"? How so? Please offer sound proof and accredited sources when answering as I'd love to learn more about this claim.

READ MY COMMENT, PLEASE.

Very interesting and informative. Thanks !!

If you reset brain cells, do they lose memory or other acquired traits? Seems like this would be the limitation. So actually, aging research might be connected to the brain-downloading research that was considered to be very far away.

your videos are nothing but amazement to me, I can see how passionate you are about every of your videos, may you have a good life

18:02 They could probably try doing the test on like house flys, mosquitos or some other creature that has increadably short life spans like that to answer that question. Sense they generally have shorter life spans, might give some insight on how many times you can reverse ageing before unforeseen side effects emerge

A video about the ethical implications of slowing and reversing ageing would be an interesting follow-up!?

i dont think that longevity creates over-population, or would have any of the problems that are typically associated with it. in fact, i think it would make things better. we would be contributing for a longer period of time. and that period of time that we actually have some smarts. one of the problems now is that we die about the time we start to understand.

1. Avoid DNA damage (wear sunscreen, avoid x-rays, etc.) 2. Eat less (fast) 3. Eat less protein 4. Exercise (HIIT) 5. Get uncomfortably cold 6. Get uncomfortably hot

just to note most sunscreens contain chemicals , we need vit d is the most important vitamin on the planet but yes everything in moderation ...2-6 excellent

Wear tuskan raider robes live in Sahara desert extreme heat and cold eat Japanese food practice thai kickboxing

Can you explain uncomfortably hot

@High Virtue ... Australia, in summer, no air con.

@High Virtue a Sauna

In terms of the five (six strategies) for increased life span/decrease your biological age, the extreme cold/heat strategies should be active for sauna lovers in colder climate (Finland, Sweden, Norway). For some (myself included) this ceremony almost becomes like a drug, and I know a lot of people who actually do this at least 5-7 times a week during the autumn/winter/spring. It should then be fairly simple to measure this effect in a longitudinal study, although you have to try to control for other underlying factors (sauna people in Sweden are a different breed than normal people, in my experience at least....). Oh and by the way, if a pharmaceutical or gene therapy that can reverse ageing eventually is realised, it will wreak modern society as we know it to pieces. There is a reason that the last couple of decades have made such strides in terms of inclusion of minorities, LBTQ issues an so on, the main reason being that the old people of power and keepers of cultural norms are dead. If that were not the case, you would see so many more examples of Brexit issues, nostalgia regarding the old "happy days" etc. It would be a conservative or even reactionary dystopia, with a few flare ups of younger generations doing the "Greta walk".

That’s why it should be illegal to research medicine. Period.

@Wolfette Plays 🤡🤡🤡

Awesome video man! great work!

"When your brain cells lose their identity and turn into skin cells, that's a problem." Didn't expect this learning experience to be this frightening. 😥

Thanks for the tutorial it really worked!

This video is one of the best on whole YouTube! I saw it first time about a year ago and after that have I promise to be at least 130 years old!

this man really dropped a mitochondria is the powerhouse of the cell into this

Huh?

Mitochondria is plural. It would be "mitochondria *are* the powerhouse*s* of the cell" , or "A mitochondri*on* *is* the power house of *a* cell."

@None Ofyerbisness I finally understand what he was trying to say. Exclamation points around "mitochondria....of the cell"; makes it grammatically make sense. Without said exclamation points; it's a word-salad.

@Rocketassistedgoat You're a bit mixed up on your punctuation marks, friend.

Its a sign of inteligence that someone can explain a really complex term using simple words

It is exciting to think that a few of us might actually become super old. We know now how to reverse aging in theory. Imagine if we have a way to slow aging down in 50 years. It could probably give you another 50 years of lifetime. But in those additional 50 years, who knows how far the technology might develope further.

its been 2 years now, can we have an update video on prof. sinclair? i think that this is one of the best video you've ever done and i cant wait for an update

Awesome video as always

Administering this molecule is one of the 2 prongs to the 2 pronged approach that would be the fountain of youth. The other prong is a procedure that turns all the stem cells of a person back into embryonic stem cells. The stem cell procedure is performed first and repeated every 20 years. The molecule administration would be performed every 6 months for a period of 7 years starting at the stem cell procedure.

Sinclair: "You can clone monkeys, dogs, Barbara Streisand the actress..." Me: "I KNEW IT!" Sinclair: "...she cloned her dog." Me: "Oh".

😳🤣👏

@Pammy M It'd be interesting to see that actress clones herself and adopting her as her child. So weird.

@Eric 🤣👏

@Eric you are talking about kanata no astra

Damn this is so underrated

I thought that cloning was a really precise process which it is, but I thought it was more complicated like you had to take the nucleus out of both and replace them and split the dna so that you could get an egg and a sperm to fertilise the egg but no - you just add the cell you want cloned to an egg cell with no nucleus and strike it with electricity (just like francinstein) to start the splitting process. Like it’s way simpler then it should be

Insane how complex the human body is thinking about how DNA works is insane

sometimes I just look at my fingers and or someone's eyeballs think about how all this is just amazing

Wow I can see why you have so many followers. Im hooked on some of these videos already, which I've stumbled upon this afternoon. This is better than I remember educación being at school all those years ago.

So basically I've been living a really good life if those are the requirements, Everything except the high intensity exercise (I do low intensity for 8h/day as a part of my job) but my genes pretty much make me do the others, and same for my granpa who at 93 can still to chin ups

Please do a video addressing the concerns around this research from Sinclairs lab... They did many experiments which failed and only published the few and far between successful results.

I love how interested Dr. Sinclair is talking about his research. Super interesting subject and I’d love to see a follow up video after his research is done.

His research is done when we can reverse aging lmao

@Shawn then we have to wait for the FDA to approve of this, and all governmental agencies. Then we have to find a way to make sure that it's not just the rich who could afford this, we have so many more steps after his research is proven successful in humans.

@Engineering Geek And then we need to stop humans from reproducing so we don't overpopulate

@Fiszt You know that overpopulation is a myth, right? With the modern economy, as education in birth control rises and standards of living rise, people will naturally be unable to afford more children. As such, countries with decently educated populations will start seeing a stagnating population or even a decreasing population (ex. Japan and Russia). The population will reach an equilibrium where the cost to raise a child will determine the number of children being born. For this to really effective, we need universal strong education, which is slowly but surely becoming reality. I mean, we now see the best and brightest minds not just coming from America/Western Europe, but from India and China. You may say that India and China are overpopulated, but I will disagree- the cost of raising a child is SUPER LOW because of the rapidly industrializing economy. Both those countries should reach their child economic support equilibria at about 1.5-1.75 billion people. This is coming from an Indian who lived in India for a while and familiar with the economy and culture there. Think about India like the preindustrial USA- a massive population boom that seems unsustainable, but once standard of living and education catch up with it, it stabilizes.

When I was 50 I was told by a Ukrainian doctor that my lungs were the age of a 70-year-old I’m now 60 and I feel like I’m 90 this is a wonderful wonderful idea good luck Fellars

Shouldn't the epigenome test be an easy experiment? You would isolate two groups right? one group in such a way to minimize DNA damage, and your control group that is just living in the cage. Using relative sample sizes couldn't you compare the length of time each sample lived and get a significant result? (Assuming you can limit damage to their DNA, not a scientist 😔)

we want part 2 now its been 3 years!

I remember when the NASA twins were studied. The buzz on the internet was that the one who spent a year in space had actual growth of his telomeres or less of a reduction of his telomeres. It was quite the excited buzz within comment sections and chat rooms from people who understand what that means concerning health, longevity and living in space over long periods of time. Far beyond what I know, but I also have an acute interest -- we all want to live forever, right? I seem to understand it better now, but would love to see your show explore genetics, evolution, environmental engineering and just what about us that makes us human. I love your show! Best to you!

This guy needs to touch on this again since the new science came out!

So if i am understanding correctly, the goal of intermittent fasting and amino acids restriction is to make your body believe you are in a dangerous environment, activating your longevity genes responsible for repairing the parts of your cell that represent your age. the longer your body stays in longevity mode, the longer your epigenome preserves your age. That would explain why monks in temples without air conditioning who eat intermittently and very little, also have longer lifespans and healthier bodies. I can't wait to see how this research develops. Please keep us updated i would love to see more on this topic.

And practice celibacy too !

Oh well, there goes long life!

I do this naturally to save on food stamps and electricity so I should live to be 1000..

Fun For all maybe its because they dont eat procesed food and actually are less stressed in their simple life then people living in modern society.

Read "The longevity diet" by Valter Longo

So what I'm hearing is... when One Punch talked about not using the aircon even though it's super hot, to save money, and only eating when there's a good special on... these were actually core parts of his training

One of the worst parts of dracula is near immortality. Our life spans were shortened to avoid suffering and at least for me I'm sticking to it.

wow. please do another video about this since it’s been two years. what new info has been discovered in this area?

i love educational videos that view themselves as tutorials

It seems like there's this constant push and pull between physical stress as a contributor to either good health or poor health. If physical stresses like nutritional deficit and exercise do in fact slow aging, why would mental stress accelerate it? (There seems to be quite the consensus on that) Anyone have any insight on this?

Usually I never comment on videos, but this one was so remarkably well done, interesting and groundbreaking. I’m here to give a noisy applause (long lasting Veritasium fan here)

The thing with popular creators I'd they don't notice you 😔

This video is great, but not groundbreaking.

To kinda quote jurassic Park: I feel like we're going to think so much about whether we can, that we won't stop to think about whether we should. I think all the concerns you mentioned at the beginning of the video are too true to execute this no matter the benefits.

I think the benefits outweigh the negatives

This was the inspiration for my video about the topic, thanks for everything!

Its good to see science trying to advance like they did in comic books. We may be closer the -supervillan- superhero era now.